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1979•The Medical Journal of AustraliaRequires access

AMELIORATION OF CANCER CHEMOTHERAPY‐INDUCED NAUSEA AND VOMITING BY DELTA‐9‐TETRAHYDRO‐CANNABINOL

H. Ekert, Keith Waters, I. H. Jurk, J. Mobilia, Peter M Loughnan

Open publisher page 97 citations

Abstract

The antinausea and antivomiting effects of delta-9-tetrahydrocannabinol (THC) in children receiving cancer chemotherapy were compared with those of metoclopramide syrup and prochlorperazine tablets in two double-blind studies. THC was found to be a significantly better antinausea and antivomiting agent, but not all patients obtained relief of nausea and vomiting with THC. In some patients, THC enhanced appetite during a course of chemotherapy. In two patients, a "high" associated with THC administrationwas reported. Drowsiness was reported significantly more frequently with THC.

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What this paper is about

The antinausea and antivomiting effects of delta-9-tetrahydrocannabinol (THC) in children receiving cancer chemotherapy were compared with those of metoclopramide syrup and prochlorperazine tablets in two double-blind studies. THC was found to be a significantly better antinausea and antivomiting agent, but not all patients obtained relief of nausea and vomiting with THC. In some patients, THC enhanced appetite during a course of chemotherapy. In two patients, a "high" associated with THC administrationwas reported. Drowsiness was reported significantly more frequently with THC.

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OpenAlex reports 97 citations for this work. Citation counts describe recorded attention and do not establish research quality.

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Available abstract

The antinausea and antivomiting effects of delta-9-tetrahydrocannabinol (THC) in children receiving cancer chemotherapy were compared with those of metoclopramide syrup and prochlorperazine tablets in two double-blind studies. THC was found to be a significantly better antinausea and antivomiting agent, but not all patients obtained relief of nausea and vomiting with THC. In some patients, THC enhanced appetite during a course of chemotherapy. In two patients, a "high" associated with THC administrationwas reported. Drowsiness was reported significantly more frequently with THC.

Key concepts: Prochlorperazine, Nausea, Vomiting, Cannabinol, Metoclopramide, Medicine, Chemotherapy, Cancer chemotherapy

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AMELIORATION OF CANCER CHEMOTHERAPY‐INDUCED NAUSEA AND VOMITING BY DELTA‐9‐TETRAHYDRO‐CANNABINOL — Research Paper | ScholarLens