2011•LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas)Open access
Maldi-imaging for proteomics of protease inhibitors
J. Bromsoms, Stephen J. Trejo, Jana Alonso Lorenzo, Patricia Marín‐García, José M. Bautista, Francesc Avilés
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Abstract
MALDI-imaging mass spectrometry (MALDI-IMS) is a novel experimental approach to visualize the distribution of biomolecules on tissue sections [1]. Proteins, peptides, lipids and metabolites can be analyzed in a selective and/or highthroughput manner. The application of IMS allows acquisition of protein and peptide profiles, biomarker discovery, biomarker localization, tissue classification or cancer diagnosis and prognosis [1,2]. In this study we report the distribution of protease inhibitors in several mouse tissues, after intraperitoneal injection.