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1999•The Indian Journal of Animal SciencesOpen access

Multiple anthelmintic resistance in Haemonchus contortus of sheep

C.P. Swarnkar, D. Singh, Faiz Ahmad Khan, P.S.K. Bhagwan

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Abstract

Faecal egg count reduction test (FECRT) and in vitro egg hatch assay (EHA) detected anthelmintic resistance in Haemonchus contortus in sheep. On FECRT, fenbendazole and tetramisole were, respectively, found 0 and 25% effective against H. contortus, while closantel showed 100% efficacy. Though rafoxanide was 96% effective against H. contortus, but lower 95% confidence limit of less than 90 suggested suspected resistance against the rafoxanide. The EHA showed LC₅₀ value of 0.265 ± 0.098 µg thiabendazole / ml against H. contortus. It was concluded that H. contortus developed resistance against benzimidazole, tetramisole and low level resistance against rafoxanide.

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What this paper is about

Faecal egg count reduction test (FECRT) and in vitro egg hatch assay (EHA) detected anthelmintic resistance in Haemonchus contortus in sheep. On FECRT, fenbendazole and tetramisole were, respectively, found 0 and 25% effective against H. contortus, while closantel showed 100% efficacy. Though rafoxanide was 96% effective against H. contortus, but lower 95% confidence limit of less than 90 suggested suspected resistance against the rafoxanide. The EHA showed LC₅₀ value of 0.265 ± 0.098 µg thiabendazole / ml against H. contortus. It was concluded that H. contortus developed resistance against benzimidazole, tetramisole and low level resistance against rafoxanide.

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Available abstract

Faecal egg count reduction test (FECRT) and in vitro egg hatch assay (EHA) detected anthelmintic resistance in Haemonchus contortus in sheep. On FECRT, fenbendazole and tetramisole were, respectively, found 0 and 25% effective against H. contortus, while closantel showed 100% efficacy. Though rafoxanide was 96% effective against H. contortus, but lower 95% confidence limit of less than 90 suggested suspected resistance against the rafoxanide. The EHA showed LC₅₀ value of 0.265 ± 0.098 µg thiabendazole / ml against H. contortus. It was concluded that H. contortus developed resistance against benzimidazole, tetramisole and low level resistance against rafoxanide.

Key concepts: Haemonchus contortus, Anthelmintic, Fenbendazole, Veterinary medicine, Biology, Benzimidazole, Animal science, Nematode

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