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2003•Humana Press eBooksOpen access

Etiology and Pathogenesis of Inflammatory Bowel Disease

James J. Farrell, Bruce E. Sands

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Abstract

Despite improved understanding of the mechanisms of intestinal inflammation, the etiology and pathogenesis of inflammatory bowel disease (IBD) remain obscure. Hence, the approaches to the diagnosis and management of both Crohn’s disease (CD) and ulcerative colitis (UC) have been largely empiric. However, progress in IBD research has fostered development of new agents that target pivotal processes in disease pathogenesis (1). This chapter addresses the etiology and pathogenesis of IBD, including the latest developments in animal models. It will serve as a basis for understanding current and future therapeutic development.

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What this paper is about

Despite improved understanding of the mechanisms of intestinal inflammation, the etiology and pathogenesis of inflammatory bowel disease (IBD) remain obscure. Hence, the approaches to the diagnosis and management of both Crohn’s disease (CD) and ulcerative colitis (UC) have been largely empiric. However, progress in IBD research has fostered development of new agents that target pivotal processes in disease pathogenesis (1). This chapter addresses the etiology and pathogenesis of IBD, including the latest developments in animal models. It will serve as a basis for understanding current and future therapeutic development.

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Available abstract

Despite improved understanding of the mechanisms of intestinal inflammation, the etiology and pathogenesis of inflammatory bowel disease (IBD) remain obscure. Hence, the approaches to the diagnosis and management of both Crohn’s disease (CD) and ulcerative colitis (UC) have been largely empiric. However, progress in IBD research has fostered development of new agents that target pivotal processes in disease pathogenesis (1). This chapter addresses the etiology and pathogenesis of IBD, including the latest developments in animal models. It will serve as a basis for understanding current and future therapeutic development.

Key concepts: Pathogenesis, Etiology, Inflammatory bowel disease, Ulcerative colitis, Disease, Medicine, Crohn's disease, Immunology

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