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寻常痤疮患者血清和皮损中SP、IL-1、IL-6的研究

钟建桥, 先德海, 陈德宇

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Abstract

Objective: To study the role of Substance P (SP) in the pathogenesis of acne vulgaris. Methods: ELISA was used to measuer the levels of SP, Interleukin-1 (IL-1) and Interleukin-6 (IL-6) in Serum and Lesion from 64 patients with acne vulgaris and 32 normal controls. Results: The Serum and Lesion levels of SP, IL-1 and IL-6 in acne vulgaris were significantly higher than those in normal controls (P＜0.01); There were no significant differences in SP, IL-1 and IL-6 levels between the patients with Ⅰ, Ⅱ degree and those with Ⅲ, Ⅳ degree of acne vulgaris. Conclusion: These findings indicate that SP may be closely assoiated with the etiology of acne vulgaris and play a important role in the pathogenesis of the disease.

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What this paper is about

Objective: To study the role of Substance P (SP) in the pathogenesis of acne vulgaris. Methods: ELISA was used to measuer the levels of SP, Interleukin-1 (IL-1) and Interleukin-6 (IL-6) in Serum and Lesion from 64 patients with acne vulgaris and 32 normal controls. Results: The Serum and Lesion levels of SP, IL-1 and IL-6 in acne vulgaris were significantly higher than those in normal controls (P＜0.01); There were no significant differences in SP, IL-1 and IL-6 levels between the patients with Ⅰ, Ⅱ degree and those with Ⅲ, Ⅳ degree of acne vulgaris. Conclusion: These findings indicate that SP may be closely assoiated with the etiology of acne vulgaris and play a important role in the pathogenesis of the disease.

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Available abstract

Objective: To study the role of Substance P (SP) in the pathogenesis of acne vulgaris. Methods: ELISA was used to measuer the levels of SP, Interleukin-1 (IL-1) and Interleukin-6 (IL-6) in Serum and Lesion from 64 patients with acne vulgaris and 32 normal controls. Results: The Serum and Lesion levels of SP, IL-1 and IL-6 in acne vulgaris were significantly higher than those in normal controls (P＜0.01); There were no significant differences in SP, IL-1 and IL-6 levels between the patients with Ⅰ, Ⅱ degree and those with Ⅲ, Ⅳ degree of acne vulgaris. Conclusion: These findings indicate that SP may be closely assoiated with the etiology of acne vulgaris and play a important role in the pathogenesis of the disease.

Key concepts: Acne, Pathogenesis, Etiology, Lesion, Medicine, Interleukin, Disease, Interleukin 6

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寻常痤疮患者血清和皮损中SP、IL-1、IL-6的研究 — Research Paper | ScholarLens