The Important Genes for Fracture Healing (Molecular Aspects)

Fracture healing is a complex physiological process. Several components are involved for the healing process, including periosteum (one of the precursors cells which develop into osteoblast and chondroblast lineage), bone marrow, cortex, and external soft tissue are other sources of the precursor cells. Various phases of fracture healing such as migration, proliferation, differentiation and inhibition are recovery facilitate in this healing. Although the histological characteristics of fracture healing are clear and well known, further understanding of cellular and molecular aspects is a critical for enhance the knowledge. The essential signalling molecules such as BMPs (bone morphogenetic protein), Wnts, their sources, targeted cells, interaction, synergy during fracture healing is presented in this article.