Ceftriaxone resistance in Neisseria gonorrhoeae: research advances.

Ceftriaxone is a first-line drug for Neisseria gonorrhoeae treatment.In vitro antimicrobial susceptibility studies have found few N.gonorrhoeae strains resistant to ceftriaxone,though clinical ceftriaxone treatment failure has not been reported worldwide.Furthermore,ceftriaxone resistance rates are above 5% in few areas of China.In view of the tendency of N.gonorrhoeae less susceptible to ceftriaxone,it is necessary to monitor ceftriaxone resistance to N.gonorrhoeae.Nowadays the mechanism of ceftriaxone resistance has not been fully elucidated,most studies focus on mutations in the penA and mtrR genes.