2006•Chinese Chemical LettersRequires access

Synthesis and Anticancer Effect of gem-Difluoromethylenated Chrysin Derivatives

Xing Zheng, Jianguo Cao, Duan‐Fang Liao, Bing‐Yang Zhu, Huiting Liu

Abstract

Ten gem-difluoromethylenated chrysin derivatives were prepared and their anticancer activities in vitro were evaluated by the standard MIT method. The results of biological test showed that some of gem-difluoromethylenated chrysin derivatives had higher anticancer activity than chrysin.

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Key concepts: Chrysin, Chemistry, In vitro, Combinatorial chemistry, Pharmacology, Stereochemistry, Organic chemistry, Biochemistry