1954•Journal of Biological ChemistryOpen access

GLUTAMIC ACID INHIBITION OF ASPARTIC ACID UTILIZATION IN THREONINE BIOSYNTHESIS

Joanne M. Ravel, Barbara Felsing, William Shive

Abstract

The observation that Leuconostoc dextranicum 8086 requires either aspartic acid or threonine for growth resulted in studies in which a ri%e’ of aspartic acid in the biosynthesis of threonine was demonstrated in certain lactobacilli (1). In the present investigation, the nature of the requirement for either aspartic acid or threonine for growth of L. dextranicum 8086 has been found to be the result of a competitive inhibition by glutamic acid of the utilization of aspartic acid in the biosynthesis of threonine.

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Key concepts: Aspartic acid, Threonine, Biochemistry, Biosynthesis, Glutamic acid, Chemistry, Amino acid, Amino acid synthesis