Forms of focal epilepsy in children and their treatment with antiepileptic drug of different generations

Aim. To conduct a comparative clinical analysis of the effectiveness of treatment with different generations of antiepileptic drugs in children with focal forms of epilepsy. Methods. Examined were 96 patients aged from one month to 17 years with focal forms of epilepsy treated with antiepileptic drugs of different generations (phenobarbital, topiramate or lamotrigine). Results. Positive results in the treatment (complete relief of seizures or reduction of their frequency by 50% or more) was achieved in 87% of patients receiving topiramate, in 71% lamotrigine and in 38% -phenobarbital. Conclusions. New antiepileptic drugs topiramate and lamotrigine showed a higher efficacy in the treatment of focal forms of epilepsy in children than phenobarbital.