ScholarLens Back to search
2005•Kluwer Academic Publishers eBooksRequires access

Calpain Isoforms in the Eye

Thomas R. Shearer, Hong Ma, M. Shih, Kirsten J. Lampi, Chiho Fukiage, Miyuki Azuma

Open publisher page 0 citations

Abstract

Retina and lens from rodents contain at least five newly discovered isoforms of calpain (Lp82, Lp85, Rt88, Rt88′ and Rt90), in addition to the ubiquitous calpains. Unexpectedly, these isoforms were related to muscle-preferred p94. Although some of their biochemical characteristics are known, the current challenge is to discover the functions of calpain isoforms under normal and pathological conditions. Further, because of stop codons, orthologues of the isoforms discussed above do not exist in man. Another challenge is to relate the rodent data to the human situation. For example, do undiscovered calpain isoforms performing the same functionsas Lp82, Lp85, Rt88 and Rt90 exist in human eye?

About this research paper

What this paper is about

Retina and lens from rodents contain at least five newly discovered isoforms of calpain (Lp82, Lp85, Rt88, Rt88′ and Rt90), in addition to the ubiquitous calpains. Unexpectedly, these isoforms were related to muscle-preferred p94. Although some of their biochemical characteristics are known, the current challenge is to discover the functions of calpain isoforms under normal and pathological conditions. Further, because of stop codons, orthologues of the isoforms discussed above do not exist in man. Another challenge is to relate the rodent data to the human situation. For example, do undiscovered calpain isoforms performing the same functionsas Lp82, Lp85, Rt88 and Rt90 exist in human eye?

Why it matters

A significance statement is not available in the OpenAlex record.

Key contribution

A contribution statement is not available in the OpenAlex record.

Method / approach

Method details are not available in the OpenAlex metadata.

Main findings

Findings are not separately available in the OpenAlex metadata.

Limitations

Limitations are not available in the OpenAlex metadata.

Applications

Application details are not available in the OpenAlex metadata.

Available abstract

Retina and lens from rodents contain at least five newly discovered isoforms of calpain (Lp82, Lp85, Rt88, Rt88′ and Rt90), in addition to the ubiquitous calpains. Unexpectedly, these isoforms were related to muscle-preferred p94. Although some of their biochemical characteristics are known, the current challenge is to discover the functions of calpain isoforms under normal and pathological conditions. Further, because of stop codons, orthologues of the isoforms discussed above do not exist in man. Another challenge is to relate the rodent data to the human situation. For example, do undiscovered calpain isoforms performing the same functionsas Lp82, Lp85, Rt88 and Rt90 exist in human eye?

Key concepts: Calpain, Gene isoform, Biology, Cell biology, Focus (optics), Neuroscience, Biochemistry, Gene

Related papers

Related paper 1Related paper 2Related paper 3
Back to paper searchBrowse research topicsOriginal source
Calpain Isoforms in the Eye — Research Paper | ScholarLens