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Apoptosis of liver cancer SMMC7721 cell line induced by curcumin

Lu-juan Shan, Qiu Yang, Huishu Guo, Li Guo, Yuejian Liu, Taihua Wu

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Abstract

[Objective] This study is to investigate the effect of curcumin on growth and apoptosis of human liver canner SMMC7721 cell line and its mechanism.[Methods] The effect of curcumin on proliferation of cell line SMMC7721 was examined through MTT assay.The effect of curcumin on the apoptosis and chondrisome membrane potential of SMMC7721 cells were tested by flow cytometry.[Results] Curcumin inhibited the proliferation of SMMC7721 cells in a time and dose dependent manner(P0.01).Concentrations of 6.25 to 50 μmol/L of curcumin for 24 hours induced apoptosis rate of SMMC7721 cells were 6.3%,7.2%,37.3% and 72.3% respectively,and decreased chondrisome membrane potential at 6.3%,13.8%,47.8% and 87.9% respectively.[Conclusion] Curcumin may induce apoptosis of SMMC7721 cells by inhibiting proliferation of the cells,which is possible to be related to the decreased chondrisome membrane potential.

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What this paper is about

[Objective] This study is to investigate the effect of curcumin on growth and apoptosis of human liver canner SMMC7721 cell line and its mechanism.[Methods] The effect of curcumin on proliferation of cell line SMMC7721 was examined through MTT assay.The effect of curcumin on the apoptosis and chondrisome membrane potential of SMMC7721 cells were tested by flow cytometry.[Results] Curcumin inhibited the proliferation of SMMC7721 cells in a time and dose dependent manner(P0.01).Concentrations of 6.25 to 50 μmol/L of curcumin for 24 hours induced apoptosis rate of SMMC7721 cells were 6.3%,7.2%,37.3% and 72.3% respectively,and decreased chondrisome membrane potential at 6.3%,13.8%,47.8% and 87.9% respectively.[Conclusion] Curcumin may induce apoptosis of SMMC7721 cells by inhibiting proliferation of the cells,which is possible to be related to the decreased chondrisome membrane potential.

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Available abstract

[Objective] This study is to investigate the effect of curcumin on growth and apoptosis of human liver canner SMMC7721 cell line and its mechanism.[Methods] The effect of curcumin on proliferation of cell line SMMC7721 was examined through MTT assay.The effect of curcumin on the apoptosis and chondrisome membrane potential of SMMC7721 cells were tested by flow cytometry.[Results] Curcumin inhibited the proliferation of SMMC7721 cells in a time and dose dependent manner(P0.01).Concentrations of 6.25 to 50 μmol/L of curcumin for 24 hours induced apoptosis rate of SMMC7721 cells were 6.3%,7.2%,37.3% and 72.3% respectively,and decreased chondrisome membrane potential at 6.3%,13.8%,47.8% and 87.9% respectively.[Conclusion] Curcumin may induce apoptosis of SMMC7721 cells by inhibiting proliferation of the cells,which is possible to be related to the decreased chondrisome membrane potential.

Key concepts: Curcumin, Apoptosis, Flow cytometry, Chemistry, Cell culture, Cell growth, Cell, Membrane potential

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