In Vivo Dose—Response Effects of Mpl Ligands on Platelet Production and Function

Thrombopoietin (TPO), the endogenous Mpl ligand, maintains peripheral platelet concentrations at a constant level by modulating megakaryocytopoiesis to compensate for changing peripheral requirements (1–6) . TPO promotes platelet production by inducing hemopoietic stem cells to differentiate into megakaryocytes (3,7–9) , and stimulating megakaryocyte proliferation and endoreduplication (3,10–16) , thereby amplifying formation of the megakaryocyte cytoplasmic substrate destined for fragmentation and release as functional circulating platelets (17–19) (see Chapters 14–17). These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.