2007•CirculationRequires access
Abstract 290: Cardiac Myocyte Gq Signaling Decreases Cardiac Function During Chronic High Blood Pressure Through Cardiac Remodeling
David M. Harris, Xiongwen Chen, Stéphanie Pesant, Heather I. Cohn, Scott M. MacDonnell, Mattieu Boucher, Korin Faulkner, Maggie Shapiro, Patrick Most, Steven R. Houser, Walter J. Koch, Andrea D. Eckhart
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Abstract
Chronic pressure overload and elevated levels of neurohormones initiate cardiac hypertrophy(HYP) and dysfunction. These neurohormones bind to Gq protein-coupled receptors which are an integral part...