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2015•Bioorganic & Medicinal ChemistryOpen access

The importance of the 6- and 7-positions of tetrahydroisoquinolines as selective antagonists for the orexin 1 receptor

David A. Perrey, Ann Marie Decker, Jun‐Xu Li, Brian P. Gilmour, Brian F. Thomas, Danni L. Harris, Scott P. Runyon, Yanan Zhang

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Key concepts: Antagonism, Chemistry, Tetrahydroisoquinoline, Stereochemistry, Orexin, Receptor, Potency, Pharmacology

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The importance of the 6- and 7-positions of tetrahydroisoquinolines as selective antagonists for the orexin 1 receptor — Research Paper | ScholarLens