1992•PubMedRequires access
The influence of endotracheal bleomycin administration on phospholipid composition of rat lung surfactant.
Andrzej Ledwozyw, T Ruciński, R Synowiec
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Abstract
The influence of intratracheal bleomycin instillation (10 mg x kg-1) on lung surfactant phospholipids in rats after 7 and 14 days from drug administration was evaluated. It was stated that bleomycin causes a great fall in phosphatidylcholine, disaturated phosphatidylcholine and phosphatidylglycerol content, both in extra- and intracellular pool of surfactant. The data thus presented evidenced that intratracheal bleomycin administration caused a profound changes in the lipid composition of rat lung surfactant.