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2002•Swiss Medical WeeklyOpen access

Gemcitabine-related pulmonary toxicity

A Gunz, BC Pestalozzi

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Abstract

BACKGROUND: Gemcitabine is an increasingly used and generally well tolerated anticancer drug. Rarely, it leads to potentially fatal pulmonary toxicity. CASE DESCRIPTIONS AND RESULTS: We describe the clinical features of 5 patients with gemcitabine-related pulmonary toxicity. Due to early diagnosis, prompt discontinuation of the drug, and treatment with steroids, toxicity was reversible in all cases. CONCLUSION: Early recognition of gemcitabine-related pulmonary toxicity is mandatory.

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What this paper is about

BACKGROUND: Gemcitabine is an increasingly used and generally well tolerated anticancer drug. Rarely, it leads to potentially fatal pulmonary toxicity. CASE DESCRIPTIONS AND RESULTS: We describe the clinical features of 5 patients with gemcitabine-related pulmonary toxicity. Due to early diagnosis, prompt discontinuation of the drug, and treatment with steroids, toxicity was reversible in all cases. CONCLUSION: Early recognition of gemcitabine-related pulmonary toxicity is mandatory.

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Available abstract

BACKGROUND: Gemcitabine is an increasingly used and generally well tolerated anticancer drug. Rarely, it leads to potentially fatal pulmonary toxicity. CASE DESCRIPTIONS AND RESULTS: We describe the clinical features of 5 patients with gemcitabine-related pulmonary toxicity. Due to early diagnosis, prompt discontinuation of the drug, and treatment with steroids, toxicity was reversible in all cases. CONCLUSION: Early recognition of gemcitabine-related pulmonary toxicity is mandatory.

Key concepts: Gemcitabine, Medicine, Pulmonary toxicity, Toxicity, Discontinuation, Drug, Drug toxicity, Antimetabolite

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