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Kinetics of strontium-85 absorption by bone tissues of rats in vivo and in vitro
M.M. Golutvina, N.N. Kononykina, N.E. Borisov
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Abstract
The kinetics of the absorption of /sup 85/Sr by bone tissue in the first minutes and hours after a single intravenous injection of the isotope were studied. It was shown that the isotopic content in the skeletal tissue of the rat rapidly increased, and by 6 hrs after the injection 74% of the injected quantity is accumulated; of this 7.2% is located in the organic matrix of the bone and 92.8% in the bone mineral. The kinetic parameters of the fast and capacious stages of the isotope absorption process in the living organism are close to the parameters obtained earlier in the in vitro tests. The process of rapid /sup 85/Sr absorption in living bone tissue apparently represents the kinetic exchange of ions on the surface of the hydroxylapatite crystal. (tr- auth)