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[Synthesis and biological activity of 1,4-benzoquinone-guanylhydrazone-thiosemicarbazone analogs. 1. Substitution at the S atom].

Werner Schulze, Walter Gutsche, Klaus Wohlrabe, W. F. Fleck, DIETER TRESSELT

Abstract

The synthesis of S-substituted derivatives of 1,4-benzoquinone-guanylhydrazone-thiosemicarbazone is described. The obtained 1,4-benzoquinone-guanylhydrazone-S-alkyl (resp. aralkyl)-isothiosemicarbazones, in comparison with the unsubstituted standard compound, showed a significantly decreased biological activity against the murine leukemias L 1210 and P 388 as well as against the growth of several kinds of bacteria. Therefore the S-substitution seems not to be useful for reaching a maximum activity.

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Available abstract

Key concepts: Semicarbazone, Chemistry, 1,4-Benzoquinone, Alkyl, Benzoquinone, Substitution (logic), Medicinal chemistry, Biological activity