[Influence of chlorpromazine and reserpine on the metabolism of cerebral phospholipids in the rat].
L. Rochus, Gérard Sterckx, Joannes Reuse
Abstract
L. Rochus, Gérard Sterckx, Joannes Reuse
Abstract
The effects of i.p. chlorpromazine or reserpine on the incorporation of 32P into different phospholipid fractions of rat brain were studied. Incorporation from 32P was decreased in all fractions by chlorpromazine and in some fractions only by reserpine pretreatment. Although chlorpromazine pretreatment caused an increased radioactivity level in blood plasma inorganic phosphate, brain inorganic phosphate level was the same after both drugs.
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The effects of i.p. chlorpromazine or reserpine on the incorporation of 32P into different phospholipid fractions of rat brain were studied. Incorporation from 32P was decreased in all fractions by chlorpromazine and in some fractions only by reserpine pretreatment. Although chlorpromazine pretreatment caused an increased radioactivity level in blood plasma inorganic phosphate, brain inorganic phosphate level was the same after both drugs.
Key concepts: Chlorpromazine, Reserpine, Chemistry, Metabolism, Phosphate, Pharmacology, Phospholipid, Endocrinology