1995•Korean Journal of Food Science and TechnologyRequires access
Effect of Brown Rice Extract on Mitomycin C-Induced Chromosome Aberration in Cultured CHL Cells
Hyang-Sook Chun, In Ho Kim, Hyun Jung Kim
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Abstract
The effect of brown rice extract on mitomycin C(MMC)-induced chromosome aberration was examined in cultured Chinese hamster lung(CHL) cells, after induction of chromosome aberration and mitotic index in CHL cells cultured with MMC were observed. There were no significant differences between mitotic indices of CHL cells treated with DMSO, and MMC and brown rice extract. The frequency of chromosome aberration showed dose-dependent relationship in CHL cells treated with /assay of MMC. But chromosome aberrations could not be assayed Our to cytotoxicity of MMC when its concentrations were above /assay. Chromatid type, especially gap and break, of chromosome aberration were most frequently observed. When CHL cells treated with /assay of MMC and brown rice extracts of concentration ranging /assay were incubated, frequencies of chromosome aberration induced by MMC were significantly decreased at above concentrations(p, in some irregularity.