皮肤血管瘤组织中survivin、Caspase-3的表达及意义

Objective To investigate the expression and significance of apoptosis-related survivin, Caspase-3 in human dermal hemangioma. Method Survivin and Caspase-3 were determined by immunohistochemical in human dermal hemangioma. Results The positive rates of survivin and casepase-3 were 76.9%, 35.7%, and 25.0% and 23.1%, 78.6%, 0 in turn in prolifertive hemangioma, involuting hemangioma and vascular malformations. The expression of survivin was correlated with casepase-3 (r=-0.400, P＜0.05). In voluting hemangioma and vascular malformations cases, the expression of survivin and Caspase-3 were significant difference in prolifertive hemangioma (P＜0.05). Conclusion The low expression of survivin and Caspase-3 may play a coordinated role in human dermal hemangioma.