2013•Annals of the Russian academy of medical sciencesOpen access

KYNURENINES IN PATHOGENESIS OF ENDOGENOUS PSYCHIATRIC DISORDERS

Yuri Shilov, Bezrukov Mv

Abstract

The essential amino acid tryptophan is metabolized on the methoxyindole pathway to serotonin, melatonin and 5-hydroxyindoleacetic acid and on the kynurenine pathway to kynurenine and related neuroactive metabolites, including 3-hydroxykynurenine, kynurenic acid, quinolinic acid and xanthurenic acid. Kynurenine and related metabolites play a significant role in the pathogenesis of major depressive disorder and schizophrenia. This paper is the review of literature data on the most modern state of this problem.

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Key concepts: Kynurenic acid, Xanthurenic acid, Quinolinic acid, Kynurenine, Kynurenine pathway, Melatonin, Pathogenesis, Schizophrenia (object-oriented programming)