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Micro in vitro assessment of Plasmodium falciparum sensitivity to chloroquine and mefloquine in Gujarat.

Prasanta Ray Karmakar, Suparna Dutt, M. V. V. L. Narasimham, R C Sharma

Abstract

Micro in vitro tests conducted in 1987 in Surat district of Gujarat on sensitivity status of P. falciparum to chloroquine and mefloquine revealed that the parasite has developed resistance to chloroquine upto 32 pmol. The ED 99 in Hazira, Gothan and Umra areas of the district was found to be 17.3, 18.5 and 8.7 pmol/well for chloroquine and for mefloquine it was 14.5, 4.8 and 6.8 pmol/well respectively. Monitoring of P. falciparum resistance is indicated under National Malaria Eradication Programme.

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Key concepts: Mefloquine, Chloroquine, Plasmodium falciparum, Malaria, In vitro, Protozoal disease, Pharmacology, Parasite hosting