Relation of Fasting and Postprandial Plasma Glucose to GlycosylatedHemoglobin in Diabetic patients

Background: To assess the effect of fasting plasma glucose (FPG) and two-hour postprandial plasma glucose (2hpp) levels on glycosylated hemoglobin (HbA1C). Methods: In this descriptive, cross-sectional study 300 patients were enrolled, assessed, and followed at Diabetic Center of the University of Medical Science Hamedan, Iran. All were diagnosed type 1 or 2 Diabetes mellitus. We assessed FPG and 2hpp plasma glucose at baseline and at every two weeks to one month, as needed. HbA1C was assessed at the end of study. Results were analyzed by Pierson Covariance and Multiple Regression methods. Results: The mean plasma glucose in 3 groups of HbA1C (good to fair) were 148.5±56.80 mg/dl at fasting, and 199.70±53.01 mg/dl at 2 hour after breakfast (2hpp) and mean concentration of glycosylated hemoglobin were 8.41±1.1percent. Conclusion: The postprandial plasma glucose had more association to glycosylated hemoglobin than fasting plasma glucose, therefore, evaluating postprandial plasma glucose should be a preferred method for glucose monitoring. (Rawal Med J 2008;33:12- 14).