Sodium-22 transport as an index of cell membrane status following gamma irradiation. [Mice]
R.M. Malkina
Abstract
R.M. Malkina
Abstract
Mice were exposed to 900 R of gamma radiation and /sup 22/Na was injected intraperitoneally into irradiated as well as unirradiated control mice. The concentration of /sup 22/Na in blood, liver, and spleen was assayed. Results showed that following exposure to radiation there were changes in ion permeability of membranes manifested by accumulation of /sup 22/Na in organs. It is suggested that the change in ion permeability may serve as a criterion of radiation injury to cell membranes. (HLW)
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Mice were exposed to 900 R of gamma radiation and /sup 22/Na was injected intraperitoneally into irradiated as well as unirradiated control mice. The concentration of /sup 22/Na in blood, liver, and spleen was assayed. Results showed that following exposure to radiation there were changes in ion permeability of membranes manifested by accumulation of /sup 22/Na in organs. It is suggested that the change in ion permeability may serve as a criterion of radiation injury to cell membranes. (HLW)
Key concepts: Membrane, Irradiation, Chemistry, Permeability (electromagnetism), Radiochemistry, Spleen, Sodium, Membrane permeability