1977Radiobiology (USSR) (Engl. Transl.); (United States)Requires access

Sodium-22 transport as an index of cell membrane status following gamma irradiation. [Mice]

R.M. Malkina

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Abstract

Mice were exposed to 900 R of gamma radiation and /sup 22/Na was injected intraperitoneally into irradiated as well as unirradiated control mice. The concentration of /sup 22/Na in blood, liver, and spleen was assayed. Results showed that following exposure to radiation there were changes in ion permeability of membranes manifested by accumulation of /sup 22/Na in organs. It is suggested that the change in ion permeability may serve as a criterion of radiation injury to cell membranes. (HLW)

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Mice were exposed to 900 R of gamma radiation and /sup 22/Na was injected intraperitoneally into irradiated as well as unirradiated control mice. The concentration of /sup 22/Na in blood, liver, and spleen was assayed. Results showed that following exposure to radiation there were changes in ion permeability of membranes manifested by accumulation of /sup 22/Na in organs. It is suggested that the change in ion permeability may serve as a criterion of radiation injury to cell membranes. (HLW)

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Available abstract

Mice were exposed to 900 R of gamma radiation and /sup 22/Na was injected intraperitoneally into irradiated as well as unirradiated control mice. The concentration of /sup 22/Na in blood, liver, and spleen was assayed. Results showed that following exposure to radiation there were changes in ion permeability of membranes manifested by accumulation of /sup 22/Na in organs. It is suggested that the change in ion permeability may serve as a criterion of radiation injury to cell membranes. (HLW)

Key concepts: Membrane, Irradiation, Chemistry, Permeability (electromagnetism), Radiochemistry, Spleen, Sodium, Membrane permeability

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