Зависимость биологической активности бактерий Bacillus sp. Из многолетнемерзлых пород от температуры

Fossil bacteria in permafrost evolutionarily adapted to low temperatures (-5°C), modern probiotics bacteria are adapted to living in warm-blooded animals (37°C). It was found that at -5°C, the enzymatic activity of fossil bacteria Bacillus sp. MG8 is a minimal strain. At lowering the incubation temperature to -16°C, the enzymatic activity of bacteria MG8 increases in 3 times, at the temperature 42°C in a 1.5times relative IP5832 strain probiotic bacteria Bacillus cereus. Fossil strain Bacillus sp. MG8 and probiotic bacterial strain B.cereus IP5832 at incubation temperature 37°C practically don''t differ from each other in the enzymatic activity in vitro and toxicity in laboratory animals in vivo. Incubation fossil bacteria Bacillus sp. at -5°C allows to reduce their toxicity in warm-blooded animals in 5 times in comparison with Bacillus cereus JP5832, and to increase immunostimulating effect in the doses from 0,005∙10 6 to 50∙10 6 microbial cells per mouse. The obtained data show that fossil saprophytic bacteria strain MG8 Bacillus sp. from permafrost are less toxic to modern mammals than even bacilli-probiotics for medical purposes.