Aplastic Anemia. Pathophysiology and Approaches to Therapy.

1 Introduction.- 2 Clinical Observations in Aplastic Anemia.- 2.1 Clinical Features of Aplastic Anaemia.- 2.2 Histology of Bone Marrow Failure, a Follow-up Study in Aplastic Anaemia.- 2.3 Epidemiology and Aetiology of Aplastic Anemia.- 2.4 The Role of Viral Infections in Aplastic Anemia.- 2.5 Aplastic Anemia Terminating in Leukemia.- 2.6 General Discussion.- 3 Kinetics and Control of Hemopoietic Stem Cells.- 3.1 Aplastic Anemia - a Stem Cell Disorder?.- 3.2 Mechanism of Damage to the Stem Cell Population.- 3.3 Congenital and Induced Defects in Haemopoietic Environments, Stem Cell Proliferation and Differentiation.- 3.4 Independent Requirements for Early and Late Stages of Erythropoiesis.- 3.5 Estimation of the Pluripotential Stem Cells in Bone Marrow After Hydroxyurea.- 3.6 CFU-C and Colony Stimulating Activity in Human Aplastic Anemia.- 3.7 Granulocytic and Erythroid Progenitor Cells in Recovering Aplastic Anemia.- 3.8 High BPA in Aplastic Anemia, a Possible Indicator of Immune Pathogenesis.- 3.9 Early and Late Effects of Adjuvant Chemotherapy (Adriamycin/Cyclophos-phamide) on the Human Granulopoiesis.- 3.10 General Discussion.- 4 The Rationale of Therapeutic Aproaches in Aplastic Anemia.- 4.1 Stimulation of Hemopoiesis in Aplastic Anemia by Hormones and Other Agents.- 4.2 Evolution of 352 Adult Patients Treated with Androgens: Short and Long Term Results of a Prospective Study.- 4.3 Insight into the Pathophysiology of Aplastic Anemia Provided Through the Results of Marrow Transplantation.- 4.4 Pathogenesis of Severe Aplastic Anemia: Inferences from Therapeutic Trials.- 4.5 Infusion of Fetal Liver Cells in Aplastic Anemia.- 4.6 Antilymphocyte Globulin Treatment in Severe Aplastic Anemia - Comparison with Bone Marrow Transplantation. Report of 60 Cases.- 4.7 Aplastic Anemia: Evidence of Immuno-Pathomechanisms and Successful Treatment with Absorbed ATG.- 4.8 The Role of Haplo-identical Bone Marrow Transfusion in ALG Treated Patients with Severe Aplastic Anemia (SAA).- 4.9 The Effect of Anthymocyte Globulin on Abnormal Lymphocyte Transformation in Patients with Aplastic Anemia.- 4.10 Recovery from Aplastic Anemia Following Therapy with Anti-thymocyte Globulin.- 5 Problems of an Immunological Pathogenesis in Aplastic Anemia.- 5.1 Some Possible Mechanisms Leading to Autoimmune Destruction of Bone Marrow Cells.- 5.2 Immunologic Function in Aplastic Anemia.- 5.3 Serum Inhibitors of Granulocyte CFU-C in Aplastic Anemia.- 5.4 Serum Inhibitors in Aplastic Anaemia.- 5.5 Aplastic Anemia After Bone Marrow Transplantation for Severe Combined Immunodeficiency.- 5.6 The Contribution of in Vitro Cultures to the Elucidation of the Pathogenesis of Aplastic Anaemia.- 5.7 Interpretations of Culture Data in Aplastic Anemia: Evidence for a Suppressor Cell Involvement.- 5.8 Co-culture Studies in Transfused and Untransfused Patients with Aplastic Anemia.- 5.9 General Discussion.- 6 Final Discussion.- 7 Summing-up.