Metoclopramide Induced Akathisia: A Case Report

Akathisia is an extrapyramidal movement disorder that is characterized objectively by an inability to sit or stand still and a subjective feeling of inner restlessness. Metoclopramide (MP) is a dopamine (D2) receptor blocker, which is widely used in emergency departments (EDs) in the treatment of patients with nausea and emesis. Like other drugs that are known to be dopamine receptor blockers, metoclopramide has been associated with extrapyramidal symptoms (EPS). Here the author presents a case of a 56 year-old male, who suffered from akathisia while being treated with MP within the therapeutic dose range for the short-term treatment of GERD. On admission to our clinic, he complained of restlessness and mental unease. Initially, MP treatment was stopped, and subsequently, diazepam 5 mg/day treatment was started. One week later the improvement in his involuntary movements as well as anxiety symptoms was impressive. In the present case report, akathisia, as a probable side effect of MP, is presented.