2000Medical Entomology and ZoologyRequires access

Translational control of gene expression

Nahum Sonenberg, John W.B. Hershey, Michael B. Mathews

Open publisher page 1,378 citations

Abstract

Origins and Principles of Translational Control (M.B. Mathews, N. Sonenberg, and J.W.B. Hershey) Pathway and Mechanism of Initiation of Protein Synthesis (J.W.B. Hershey and W.C. Merrick) Protein Bioynthesis Elongation Cycle (W.C. Merrick and J. Nyborg) Comparative View of Initiation Site Selection Mechanisms (R.J. Jackson) Mechanism and Regulation of Initiator Methionyl-tRNA Binding to Ribosomes (A.G. Hinnebusch) Regulation of Ribosomal Recruitment in Eukaryotes (B. Raught, A.-C. Gingras, and N. Sonenberg) Translational Control of Developmental Decisions (M. Wickens, E.B. Goodwin, J. Kimble, S. Strickland, and M. Hentze) Viral Translational Strategies and Host Defense Mechanisms (T. Pe'ery and M.B. Mathews) Ribosomal Subunit Joining (T.V. Pestova, T.E. Dever, and C.U.T. Hellen) Physical and Functional Interactions between the mRNA Cap Structure and the Poly(A) Tail (A. Sachs) Translation Termination: It's Not the End of the Story (E.M. Welch, W. Wang, and S.W. Peltz) Genetic Approaches to Translation Initiation in Saccharomyces cerevisiae (T.F. Donahue) Double-stranded RNA-activated Protein Kinase PKR (R.J. Kaufman) Heme-regulated eIF2 alpha Kinase (J.-J. Chen) PERK and Translational Control by Stress in the Endoplasmic Reticulum (D. Ron and H.P. Harding) Regulation of Translation Initiation in Mammalian Cells by Amino Acids (S.R. Kimball and L.S. Jefferson) Translational Control during Heat Shock (R.J. Schneider) Translational Control by Upstream Open Reading Frames (A.P. Geballe and M.S. Sachs) Cellular Internal Ribosome Entry Site Elements and the Use of cDNA Microarrays in Their Investigation (M.S. Carter, K.M. Kuhn, and P. Sarnow) Translational Control and Cancer (J.W.B. Hershey and S. Miyamoto) Translational Control of Ferritin Synthesis (T.A. Rouault and J.B. Harford) Translational Control of TOP mRNAs (O. Meyuhas and E. Hornstein) S6 Phosphorylation and Signal Transduction (S. Fumagalli and G. Thomas) Control of the Elongation Phase of Protein Synthesis (C. Proud) Programmed Translational Frameshifting, Hopping, an

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Origins and Principles of Translational Control (M.B. Mathews, N. Sonenberg, and J.W.B. Hershey) Pathway and Mechanism of Initiation of Protein Synthesis (J.W.B. Hershey and W.C. Merrick) Protein Bioynthesis Elongation Cycle (W.C. Merrick and J. Nyborg) Comparative View of Initiation Site Selection Mechanisms (R.J. Jackson) Mechanism and Regulation of Initiator Methionyl-tRNA Binding to Ribosomes (A.G. Hinnebusch) Regulation of Ribosomal Recruitment in Eukaryotes (B. Raught, A.-C. Gingras, and N. Sonenberg) Translational Control of Developmental Decisions (M. Wickens, E.B. Goodwin, J. Kimble, S. Strickland, and M. Hentze) Viral Translational Strategies and Host Defense Mechanisms (T. Pe'ery and M.B. Mathews) Ribosomal Subunit Joining (T.V. Pestova, T.E. Dever, and C.U.T. Hellen) Physical and Functional Interactions between the mRNA Cap Structure and the Poly(A) Tail (A. Sachs) Translation Termination: It's Not the End of the Story (E.M. Welch, W. Wang, and S.W. Peltz) Genetic Approaches to Translation Initiation in Saccharomyces cerevisiae (T.F. Donahue) Double-stranded RNA-activated Protein Kinase PKR (R.J. Kaufman) Heme-regulated eIF2 alpha Kinase (J.-J. Chen) PERK and Translational Control by Stress in the Endoplasmic Reticulum (D. Ron and H.P. Harding) Regulation of Translation Initiation in Mammalian Cells by Amino Acids (S.R. Kimball and L.S. Jefferson) Translational Control during Heat Shock (R.J. Schneider) Translational Control by Upstream Open Reading Frames (A.P. Geballe and M.S. Sachs) Cellular Internal Ribosome Entry Site Elements and the Use of cDNA Microarrays in Their Investigation (M.S. Carter, K.M. Kuhn, and P. Sarnow) Translational Control and Cancer (J.W.B. Hershey and S. Miyamoto) Translational Control of Ferritin Synthesis (T.A. Rouault and J.B. Harford) Translational Control of TOP mRNAs (O. Meyuhas and E. Hornstein) S6 Phosphorylation and Signal Transduction (S. Fumagalli and G. Thomas) Control of the Elongation Phase of Protein Synthesis (C. Proud) Programmed Translational Frameshifting, Hopping, an

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Available abstract

Origins and Principles of Translational Control (M.B. Mathews, N. Sonenberg, and J.W.B. Hershey) Pathway and Mechanism of Initiation of Protein Synthesis (J.W.B. Hershey and W.C. Merrick) Protein Bioynthesis Elongation Cycle (W.C. Merrick and J. Nyborg) Comparative View of Initiation Site Selection Mechanisms (R.J. Jackson) Mechanism and Regulation of Initiator Methionyl-tRNA Binding to Ribosomes (A.G. Hinnebusch) Regulation of Ribosomal Recruitment in Eukaryotes (B. Raught, A.-C. Gingras, and N. Sonenberg) Translational Control of Developmental Decisions (M. Wickens, E.B. Goodwin, J. Kimble, S. Strickland, and M. Hentze) Viral Translational Strategies and Host Defense Mechanisms (T. Pe'ery and M.B. Mathews) Ribosomal Subunit Joining (T.V. Pestova, T.E. Dever, and C.U.T. Hellen) Physical and Functional Interactions between the mRNA Cap Structure and the Poly(A) Tail (A. Sachs) Translation Termination: It's Not the End of the Story (E.M. Welch, W. Wang, and S.W. Peltz) Genetic Approaches to Translation Initiation in Saccharomyces cerevisiae (T.F. Donahue) Double-stranded RNA-activated Protein Kinase PKR (R.J. Kaufman) Heme-regulated eIF2 alpha Kinase (J.-J. Chen) PERK and Translational Control by Stress in the Endoplasmic Reticulum (D. Ron and H.P. Harding) Regulation of Translation Initiation in Mammalian Cells by Amino Acids (S.R. Kimball and L.S. Jefferson) Translational Control during Heat Shock (R.J. Schneider) Translational Control by Upstream Open Reading Frames (A.P. Geballe and M.S. Sachs) Cellular Internal Ribosome Entry Site Elements and the Use of cDNA Microarrays in Their Investigation (M.S. Carter, K.M. Kuhn, and P. Sarnow) Translational Control and Cancer (J.W.B. Hershey and S. Miyamoto) Translational Control of Ferritin Synthesis (T.A. Rouault and J.B. Harford) Translational Control of TOP mRNAs (O. Meyuhas and E. Hornstein) S6 Phosphorylation and Signal Transduction (S. Fumagalli and G. Thomas) Control of the Elongation Phase of Protein Synthesis (C. Proud) Programmed Translational Frameshifting, Hopping, an

Key concepts: Translational regulation, Ribosome, Eukaryotic initiation factor, Translational frameshift, Eukaryotic translation, EIF4E, Biology, Ribosomal protein

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