INVESTIGATION OF HEPATOPROTECTIVE ACTIVITY OF SPONDIAS PINNATA

Spondias pinnata (Anacardiaceae) stem heart wood are well known in India as Jangliaam (Hindi), Adavimaamidi, Kondamaamidi (Telugu), Common hog plum, Indian mombin (English) of ethyl acetate and methanolic extracts was prepared and tested for its hepatoprotective effect against carbon tetrachloride induced in rats. Alteration in the levels of biochemical markers of hepatic damage like SGPT, SGOT, ALP, bilirubin were tested in both treated and untreated groups. Carbon tetrachloride has enhanced the SGPT, SGOT, ALP and bilirubin levels. Treatment with ethyl acetate extract of S. pinnata stem heart wood (100, 200 and 400 mg/kg) has brought back the altered levels of biochemical markers to the near normal levels in the dose dependent manner. This was evident from significant reduction in serum enzyme, SGOT, SGPT, ALP and Total bilirubin (TB).Various pathological changes like centribular necrosis and vacuolization were observed in CCl4 treated rats, which were significant protective activity in groups treated with SP and silymarin. It was concluded from the study that ethyl acetate and methanolic extracts of SP possess hepatoprotective activity against CCl4 induced hepatotoxicity in rats.