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1996•BMJOpen access

Epidural analgesia in labour

Donal J. Buggy

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Abstract

Tuberculosis Research Unit for the streptomycin trial,4 which subsequently (from 1948) served as a model for randomisation in many later randomised controlled trials?Or is it because the results of the patulin trial were negative and those of the streptomycin trial made medical history?I have previously quoted Bradford Hill's re- collection that his statistical, and my medical, experiences in this field converged when we pre- pared for the streptomycin project.56The patulin trial certainly influenced my thinking.Yet, so far as I am aware, the literature on the modem clinical trial contains no recognition of this trial, despite its many deserving features.Should not this omission be rectified?

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What this paper is about

Tuberculosis Research Unit for the streptomycin trial,4 which subsequently (from 1948) served as a model for randomisation in many later randomised controlled trials?Or is it because the results of the patulin trial were negative and those of the streptomycin trial made medical history?I have previously quoted Bradford Hill's re- collection that his statistical, and my medical, experiences in this field converged when we pre- pared for the streptomycin project.56The patulin trial certainly influenced my thinking.Yet, so far as I am aware, the literature on the modem clinical trial contains no recognition of this trial, despite its many deserving features.Should not this omission be rectified?

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Available abstract

Tuberculosis Research Unit for the streptomycin trial,4 which subsequently (from 1948) served as a model for randomisation in many later randomised controlled trials?Or is it because the results of the patulin trial were negative and those of the streptomycin trial made medical history?I have previously quoted Bradford Hill's re- collection that his statistical, and my medical, experiences in this field converged when we pre- pared for the streptomycin project.56The patulin trial certainly influenced my thinking.Yet, so far as I am aware, the literature on the modem clinical trial contains no recognition of this trial, despite its many deserving features.Should not this omission be rectified?

Key concepts: Daphnia pulex, Parthenogenesis, Biology, Meiosis, Recombination, Genetics, Chromosomal crossover, Obligate

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