Clinial Value of Pelvic Lymph Node Micrometastasis in Early Stage Cervical Cancer by Using Immunohistochemical Method

Objective To explore the clinical value of lymph node micrometastasis by immunohischemical method with monoclonal antibody in patients with cervical cancer in early stage. Methods Immunohistochemical method was used to detect cytokeratin in 370 lymph nodes from 30 cases of cervical cancer. All patients were not given chemotherapy or radiotherapy before operation.The conventional pathological diagnosis had showed that there was no lymph node metastasis. Results 5(16.67%)of 30 cases. Among the lymph nodes with micrometata- sis,the positive rate of external iliac lymph nodes and obturator lymph nodes was 3.19% and 5.68%. the positive rate of inguinal Lymph nodes was 1.61%. the positive rate of obtutator lymph nodes was the maxlmum (P 0.05). Conclusion There is micrometastasis in the pelvic lymph nodes around the cervical cancer of early stage. The positive rate of micrometastasis inceased with the number of lymph nodes. The positive rate of obturator lymph nodes was higer than other lymph nodes. Meanwhile,the micrometastasis increases with the progression of clinical stage. These results can be hepful for the tumor stage,treatment and prognosis evaluation