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"Two route chemotherapy" using cis-diamminedichloro-platinum(II) and its antidote, sodium thiosulfate, for peritoneally disseminated cancer in rats.

Shun’ichiro Taniguchi, Tsuneo Baba

Abstract

The effects of "two route chemotherapy" using cis-diamminedichloroplatinum-(II) (DDP) and its antidote sodium thiosulfate (STS), given ip and sc, respectively, were assessed in the case of peritoneally disseminated cancer in rats. Administration of STS sc to mice 1 min before DDP ip was found to be the most effective in protecting the animals against the lethal toxicity of DDP. The LD50 values of DDP ip with and without STS were about 55 mg/kg and 14 mg/kg, respectively. This "two route chemotherapy" using DDP and STS was significantly superior in therapeutic efficacy to single treatment with DDP.

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Key concepts: Sodium thiosulfate, Antidote, Cisplatin, Pharmacology, Chemotherapy, Cancer chemotherapy, Toxicity, Thiosulfate