2011•CirculationRequires access

Oral Atorvastatin Treatment Improves NO Bioavailability and Vascular Redox State in the Human Arterial Wall, via a Tetrahydrobiopterin-Mediated Improvement of eNOS Coupling

Charalambos Antoniades, Costantinos Bakogiannis, Dimitris Tousoulis, Alexios S. Antonopoulos, Regent Lee, Michael Demosthenous, C Ratnatunga, Nikolaos Sfyras, Christodoulos Stefanadis, Keith M. Channon

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Abstract

Background: The exact mechanisms by which statins affect endothelial nitric oxide synthase (eNOS) biology in human atherosclerosis are unclear. We hypothesized that statin treatment improves nitric...

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Key concepts: Tetrahydrobiopterin, Medicine, Atorvastatin, Enos, Bioavailability, Pharmacology, Cardiology, Internal medicine