1988•The Journal of Japan Atherosclerosis SocietyOpen access

Acute Effect of High Cholesterol Diet on 3-Hydroxy-3-methylglutaryl Coenzyme A Reductase Activity in Human Peripheral Blood Mononuclear Cells

Michio Suzukawa, Takashi YAMASHITA, Kouji TOMIYASU, Masahiko NAMIKI, Masato Nishiwaki, Katsunori Ikewaki, Fumihiko Hirata, Kazuo KONDOU, Emiko MIYAJIMA, Haruo Nakamura

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Abstract

Acute effect of high cholesterol diet on 3-hydroxy-3-methylglutaryl Coenzyme A reductase (HMG CoA reductase) activity in peripheral blood mononuclear cells (PBMCs) was investigated in 5 healthy adult males. Four hours after a high cholesterol diet (fresh cream+4 boiled egg yorks), HMG CoA reductase activity decreased (p<0.1) compared to ingestion of only fresh cream. Free cholesterol content in PBMCs increased (p<0.1) after high cholesterol diet. These results suggests that down regulation of HMG CoA reductase appeared by increasing free cholesterol content in PBMCs after a high cholesterol diet.

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Key concepts: Peripheral blood mononuclear cell, Reductase, Cholesterol, Coenzyme A, HMG-CoA reductase, Hydroxymethylglutaryl-CoA reductase, Internal medicine, Endocrinology