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Anxiety states: relationship to atmospheric cations and serotonin.
Giannini Aj, Sergio Castellani, Dvoredsky Ae
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Abstract
Five cases are described that offer evidence for the existence of the "serotonin irritation syndrome," an anxiety state associated with high cation environments, elevated serum serotonin, and decreased urinary 5-hydroxyindoleacetic acid. The therapeutic response and reduction in serum serotonin after treatment with methysergide and/or removal from the high-cation environment support a serotonergic basis of the anxiety.