MORPHOLOGICAL EFFECTS OF SODIUM FLUORIDE ON HEMATOPOIETIC ORGANS IN MICE

SUMMARY: In connection with earlier studies, we examined early-response morphological effects of sodium fluoride (NaF) on hematopoietic organs in adult mice. Mature Balb C mice were given three injections of NaF in their tail veins on alternate days at total doses of 0, 10, and 50 mg NaF/kg bw. In the mice receiving NaF, morphological abnormalities were seen in the spleen as increased lymphocyte nodules, decreased white pulp, and increased red pulp infiltrated by lymphocytes. The changes were greater at the higher dose and, in other exposed mice, were still evident after three weeks. In contrast to the spleen, the liver, kidneys, and bone marrow showed little alteration.