Cartilage tissue engineering using a new self-assembling peptide gel scaffold

Emerging therapies for repair of articular cartilage include delivery of cells or cell-seeded scaffolds to a defect site to initiate de novo tissue regeneration. Biocompatible scaffolds assist in providing a template for cell distribution and extracellular matrix accumulation in a three-dimensional defect geometry. A variety of scaffolds have been investigated for cartilage repair in tissue culture and/or in animals. However, no scaffold-based cartilage construct is yet available for clinical application. In this study, we have explored the use of a novel self-assembling peptide hydrogel as a three-dimensional tissue engineering scaffold for cartilage repair [ 1 ]. These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.