Tissue-type plasminogen activator (t-PA) : physiological and clinical aspects

This book is made possible by the enthusiastic contributions of the authors of the chapters. They have been invited from young and active scientists in the field of t-PA research. I am grateful for their contribution and for the fact that all accepted the specifications of their chapter in order to obtain a structured book. Inevitably, some overlap does exist; on the one hand to enable controversial or unsettled areas to be discussed by the different experts with a different approach and background.It is a particular pleasure and honor that Dr. T. Astrup, as an eye-witness and essential contributor to the history of t-PA discovery and research, gives a unique account of the history of t-PA research in the first chapter of the book.