Effect of vitamin E and zinc supplementation on liver enzymatic profile of pre- and post-partum Sahiwal cows

The study was conducted to elucidate the changes in circulatory plasma levels of hepatic enzymes in vitamin E and zinc supplemented periparturient Sahiwal cows. Sahiwal cows (18) were selected from the institute herd, apparently healthy and in advanced state of pregnancy. The cows were randomly divided into 3 groups 6 cows in each, viz. control, treatment 1 (T1) and treatment 2 (T2). Control group was fed a control diet as practiced for pregnant cows in NDRI dairy farm. The treatment 1 (T1) group was supplemented with zinc @ 60 ppm/day/cow and treatment 2 (T2) group was supplemented a mixture of vitamin E @ 1000 IU/day/animal and zinc @ 60 ppm/ day/cow with control diet during day 60 prepartum to day 90 postpartum. Plasma was analyzed for alkalline phosphatase (ALP), alanine aminotransferase (ALT) and aspartate aminotransferase (AST). ALP levels were differing significantly in all 3 groups. ALT level was significantly lower in treatment 2 as comparison to its level of both control and treatment 1 animals. AST level was also significantly lower in treatment 2 as comparison to its level of both control and treatment 1 animals. The study indicated that vitamin E and zinc supplementation lowers these hepatic enzymes in blood plasma, prevents oxidative damage of liver and improves the health condition of liver.