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Characterization of Receptor Types for Neuropeptide Y and Related Peptides

Lars Grundemar, Søren P. Sheikh, Claes Wahlestedt

Open publisher page 56 citations

Abstract

The structurally related peptides neuropeptide Y (NPY), peptide YY (PYY), and pancreatic polypeptide (PP) are neuronal and/ or endocrine messengers that are involved in a variety of physiological processes. NPY and PYY are able to evoke potent biological effects as well as modulating responses to other transmitters. In many biological systems, NPY and PYY, but not PP seem to activate the same receptors. Because of the wide distribution of NPY in the central and peripheral nervous system compared to that of PYY, many of these actions have been attributed to NPY. These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

About this research paper

What this paper is about

The structurally related peptides neuropeptide Y (NPY), peptide YY (PYY), and pancreatic polypeptide (PP) are neuronal and/ or endocrine messengers that are involved in a variety of physiological processes. NPY and PYY are able to evoke potent biological effects as well as modulating responses to other transmitters. In many biological systems, NPY and PYY, but not PP seem to activate the same receptors. Because of the wide distribution of NPY in the central and peripheral nervous system compared to that of PYY, many of these actions have been attributed to NPY. These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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OpenAlex reports 56 citations for this work. Citation counts describe recorded attention and do not establish research quality.

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Method / approach

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Available abstract

The structurally related peptides neuropeptide Y (NPY), peptide YY (PYY), and pancreatic polypeptide (PP) are neuronal and/ or endocrine messengers that are involved in a variety of physiological processes. NPY and PYY are able to evoke potent biological effects as well as modulating responses to other transmitters. In many biological systems, NPY and PYY, but not PP seem to activate the same receptors. Because of the wide distribution of NPY in the central and peripheral nervous system compared to that of PYY, many of these actions have been attributed to NPY. These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Key concepts: Peptide YY, Neuropeptide Y receptor, Pancreatic polypeptide, Neuropeptide, Receptor, Second messenger system, Enteroendocrine cell, Endocrinology

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