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Effect of imipenem and sulbactam on sessile cells of Acinetobacter baumannii growing in biofilm.

Rosangela Regia Lima Vidal, M Domínguez, Homero Urrutia, H Bello, Apolinaria García, Glòria González, R Zemelman

Open publisher page 27 citations

Abstract

The effect of the age of biofilms formed by Acinetobacter baumannii on the activity of sulbactam and imipenem on sessile cells was investigated. Against cells of young biofilms both antibiotics were rapidly bactericidal. As the biofilm aged, sulbactam lost most of its activity, but imipenem continued to be bactericidal to some extent. This fact probably reflects the ability of imipenem to exert bactericidal activity on slow-growing bacteria.

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What this paper is about

The effect of the age of biofilms formed by Acinetobacter baumannii on the activity of sulbactam and imipenem on sessile cells was investigated. Against cells of young biofilms both antibiotics were rapidly bactericidal. As the biofilm aged, sulbactam lost most of its activity, but imipenem continued to be bactericidal to some extent. This fact probably reflects the ability of imipenem to exert bactericidal activity on slow-growing bacteria.

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OpenAlex reports 27 citations for this work. Citation counts describe recorded attention and do not establish research quality.

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Available abstract

The effect of the age of biofilms formed by Acinetobacter baumannii on the activity of sulbactam and imipenem on sessile cells was investigated. Against cells of young biofilms both antibiotics were rapidly bactericidal. As the biofilm aged, sulbactam lost most of its activity, but imipenem continued to be bactericidal to some extent. This fact probably reflects the ability of imipenem to exert bactericidal activity on slow-growing bacteria.

Key concepts: Imipenem, Biofilm, Microbiology, Acinetobacter baumannii, Sulbactam, Acinetobacter, Antibiotics, Neisseriaceae

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Effect of imipenem and sulbactam on sessile cells of Acinetobacter baumannii growing in biofilm. — Research Paper | ScholarLens