ScholarLens Back to search
1970•Scandinavian Journal of GastroenterologyRequires access

Effects of Microbial Contamination on the Cecum Enlargement of Germfree Rats

Bengt E. Gustafsson, Tore Midtvedt, Kjell Strandberg

Open publisher page 67 citations

Abstract

Gustafsson, B. E., Midtvedt, T. & Strandberg, K. 1970. Effects of Microbial Contamination on the Cecum Enlargement of Germfree Rats. Scand. J. Gastroent. 5, 309-314.Strips from germfree rat ceca were less sensitive to acetylcholine and serotonin than strips from conventional rats. Other smooth muscle organs of the germfree rat did not show a low muscular sensitivity to these agents. The effects of ‘conventionalization’ were different in young and old rats. Cecum contents were fully reduced in both age groups; cecum wall was fully reduced in young but only partially in old rats. The cecum muscular sensitivity remained unchanged in old but was ‘conventionalized’ in young rats. Monocontamination of germfree rats with Cl. difficile gave a partial reduction of the cecum contents and wall; the muscular sensitivity remained unchanged.

About this research paper

What this paper is about

Gustafsson, B. E., Midtvedt, T. & Strandberg, K. 1970. Effects of Microbial Contamination on the Cecum Enlargement of Germfree Rats. Scand. J. Gastroent. 5, 309-314.Strips from germfree rat ceca were less sensitive to acetylcholine and serotonin than strips from conventional rats. Other smooth muscle organs of the germfree rat did not show a low muscular sensitivity to these agents. The effects of ‘conventionalization’ were different in young and old rats. Cecum contents were fully reduced in both age groups; cecum wall was fully reduced in young but only partially in old rats. The cecum muscular sensitivity remained unchanged in old but was ‘conventionalized’ in young rats. Monocontamination of germfree rats with Cl. difficile gave a partial reduction of the cecum contents and wall; the muscular sensitivity remained unchanged.

Why it matters

OpenAlex reports 67 citations for this work. Citation counts describe recorded attention and do not establish research quality.

Key contribution

A contribution statement is not available in the OpenAlex record.

Method / approach

Method details are not available in the OpenAlex metadata.

Main findings

Findings are not separately available in the OpenAlex metadata.

Limitations

Limitations are not available in the OpenAlex metadata.

Applications

Application details are not available in the OpenAlex metadata.

Available abstract

Gustafsson, B. E., Midtvedt, T. & Strandberg, K. 1970. Effects of Microbial Contamination on the Cecum Enlargement of Germfree Rats. Scand. J. Gastroent. 5, 309-314.Strips from germfree rat ceca were less sensitive to acetylcholine and serotonin than strips from conventional rats. Other smooth muscle organs of the germfree rat did not show a low muscular sensitivity to these agents. The effects of ‘conventionalization’ were different in young and old rats. Cecum contents were fully reduced in both age groups; cecum wall was fully reduced in young but only partially in old rats. The cecum muscular sensitivity remained unchanged in old but was ‘conventionalized’ in young rats. Monocontamination of germfree rats with Cl. difficile gave a partial reduction of the cecum contents and wall; the muscular sensitivity remained unchanged.

Key concepts: Cecum, Caecum, Internal medicine, Biology, Anatomy, Endocrinology, Medicine

Related papers

Related paper 1Related paper 2Related paper 3
Back to paper searchBrowse research topicsOriginal source
Effects of Microbial Contamination on the Cecum Enlargement of Germfree Rats — Research Paper | ScholarLens