Local and Systemic Absorption of Parenteral and Peritoneal Administration of Ceftriaxone in Rats

High performance liquid chromatography was used to determine plasma and peritoneal fluid ceftriaxone levels after both parenteral administration and peritoneal irrigation with ceftriaxone. Ceftriaxone in amounts greater than the minimum inhibitory concentration effective against E. coli was detected in plasma of rats that received peritoneal irrigation with 1000 mg/l ceftriaxone solution; there was no ceftriaxone present in plasma of rats that received peritoneal irrigation with 10 mg/l ceftriaxone solution. Lastly, ceftriaxone irrigation was not associated with any increase in the incidence of intraabdominal adhesions in this rat model.... Antibiotic, Endotoxin, Peritoneal, Absorption.