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2024•The Ukrainian Biochemical JournalOpen access

Potential of isothiocyanate sulforaphane from broccoli to combat obesity and type 2 diabetes: involvement of NRF2 regulatory pathway

Marian V. Ivanochko, Maria M. Bayliak, Volodymyr I. Lushchak

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Abstract

Biologically active food components are now considered to be remedies for the prevention and treatment of metabolic disorders of different etiology. The aim of this review was to analyze the current data on the application of isothiocyanate sulforaphane, found in broccoli and other cruciferous plants, for the treatment of T2DM, obesity, and their comorbidities with the presentation of established molecular, particularly dependent on NF-E2-related factor-2 (Nrf2), and signaling mechanisms of therapeutic effects. Keywords: broccoli sprouts, Nrf2, nutritional therapy, obesity, preventive health, sulforaphane, type 2 diabetes mellitus

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What this paper is about

Biologically active food components are now considered to be remedies for the prevention and treatment of metabolic disorders of different etiology. The aim of this review was to analyze the current data on the application of isothiocyanate sulforaphane, found in broccoli and other cruciferous plants, for the treatment of T2DM, obesity, and their comorbidities with the presentation of established molecular, particularly dependent on NF-E2-related factor-2 (Nrf2), and signaling mechanisms of therapeutic effects. Keywords: broccoli sprouts, Nrf2, nutritional therapy, obesity, preventive health, sulforaphane, type 2 diabetes mellitus

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Available abstract

Biologically active food components are now considered to be remedies for the prevention and treatment of metabolic disorders of different etiology. The aim of this review was to analyze the current data on the application of isothiocyanate sulforaphane, found in broccoli and other cruciferous plants, for the treatment of T2DM, obesity, and their comorbidities with the presentation of established molecular, particularly dependent on NF-E2-related factor-2 (Nrf2), and signaling mechanisms of therapeutic effects. Keywords: broccoli sprouts, Nrf2, nutritional therapy, obesity, preventive health, sulforaphane, type 2 diabetes mellitus

Key concepts: Sulforaphane, Isothiocyanate, Cruciferous vegetables, Brassica, Obesity, Glucosinolate, Medicine, Type 2 diabetes

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