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Population pharmacokinetic modeling of tamoxifen and its active metabolite endoxifen in healthy volunteers of African ancestry genotyped for CYP2B6, CYP2C9, CYP2C19, CYP2D6, CYP3A4 and CYP3A5.

Shingirai Chiwambutsa, Ali M. Ali, Herbert Cubasch, Maureen Joffe, Paul Ruff, Mélanie White‐Koning, Collen Masimirembwa

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Key concepts: CYP2C19, CYP2C9, CYP2D6, CYP2B6, CYP3A5, Active metabolite, CYP3A4, Pharmacokinetics

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Population pharmacokinetic modeling of tamoxifen and its active metabolite endoxifen in healthy volunteers of African ancestry genotyped for CYP2B6, CYP2C9, CYP2C19, CYP2D6, CYP3A4 and CYP3A5. — Research Paper | ScholarLens