2024•Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and ExhibitionRequires access
Exploring the effects of tissue iron in neuromelanin MRI
Minjun Kim, Sooyeon Ji, Joonhyeok Yoon, Hwihun Jeong, Hongjun An, Ji‐Ye Kim, Jonghyo Youn, Junghwa Kang, Eung Yeop Kim, Yoonho Nam, Jongho Lee
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Abstract
Neuromelanin MRI signal decreases in IPD patients in the substantia nigra. In this study, we investigated that the decrease is caused by not only the reduction of neuromelanin but also iron deposition. Neuromelanin reduction in IPD patients was shown by the result of the substantia nigra volume decrease. The comparison result of contrast ratio, calculated between substantia nigra and crus cerebri, of IPD patients versus healthy controls demonstrated that iron deposition also decreases the signal of NM-MRI. T2*, susceptibility, and overlapped area between substantia nigra from neuromelanin MRI and hypo-intense area from SMWI also represented the tendency of iron deposition.