Electrical pulse stimulation of cultured cells as a method for mimicking exercise: A systematic review, meta-regression and meta-analysis- Raw Data for Meta-analysis and Metaregression
Eleni Nintou
Abstract
Eleni Nintou
Abstract
We performed meta-analyses to calculate the differences between control (non-stimulated) and EPS-stimulated cells for the biological indices having enough data for such an analysis. In cases of not reported values, we used WebPlotDigitizer (v4.5,2021) to extract the information from the given graphs.In cases where the number of studies was not identified, we assumed that they were conducted in triplicates and in cases of a range of number of studies, we used the mean. Since different methods and scales were utilized in the eligible studies, we used standardized mean differences (SMDs) instead of absolute mean differences to standardize our findings to uniform scale. Missing SDs were imputed using the average coefficient of variation from all complete cases.
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We performed meta-analyses to calculate the differences between control (non-stimulated) and EPS-stimulated cells for the biological indices having enough data for such an analysis. In cases of not reported values, we used WebPlotDigitizer (v4.5,2021) to extract the information from the given graphs.In cases where the number of studies was not identified, we assumed that they were conducted in triplicates and in cases of a range of number of studies, we used the mean. Since different methods and scales were utilized in the eligible studies, we used standardized mean differences (SMDs) instead of absolute mean differences to standardize our findings to uniform scale. Missing SDs were imputed using the average coefficient of variation from all complete cases.
Key concepts: Meta-analysis, Meta-regression, Stimulation, Raw data, Systematic error, Regression analysis, Medicine, Computer science