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2015•FigshareOpen access

Cyclopiazonic acid biosynthesis gene cluster gene cpaM is required for speradine A biosynthesis

Masafumi Tokuoka, Tomoki Kikuchi, Yasutomo Shinohara, Akifumi Koyama, Shin-Ichiro Iio, Takaaki Kubota, Jun’ichi Kobayashi, Yasuji Koyama, Akira Totsuka, Hitoshi Shindo, Kazuo Sato

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Abstract

Speradine A is a derivative of cyclopiazonic acid (CPA) found in culture of an Aspergillus tamarii isolate. Heterologous expression of a predicted methyltransferase gene, cpaM, in the cpa biosynthesis gene cluster of A. tamarii resulted in the speradine A production in a 2-oxoCPA producing A. oryzae strain, indicating cpaM is involved in the speradine A biosynthesis.

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What this paper is about

Speradine A is a derivative of cyclopiazonic acid (CPA) found in culture of an Aspergillus tamarii isolate. Heterologous expression of a predicted methyltransferase gene, cpaM, in the cpa biosynthesis gene cluster of A. tamarii resulted in the speradine A production in a 2-oxoCPA producing A. oryzae strain, indicating cpaM is involved in the speradine A biosynthesis.

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Available abstract

Speradine A is a derivative of cyclopiazonic acid (CPA) found in culture of an Aspergillus tamarii isolate. Heterologous expression of a predicted methyltransferase gene, cpaM, in the cpa biosynthesis gene cluster of A. tamarii resulted in the speradine A production in a 2-oxoCPA producing A. oryzae strain, indicating cpaM is involved in the speradine A biosynthesis.

Key concepts: Biosynthesis, Gene cluster, Cyclopiazonic acid, Gene, Cluster (spacecraft), Chemistry, Biochemistry, Computational biology

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Cyclopiazonic acid biosynthesis gene cluster gene cpaM is required for speradine A biosynthesis — Research Paper | ScholarLens